Engineered Circular RNA CircmiR‐29b Attenuates Muscle Atrophy by Sponging MiR‐29b (Adv. Therap. 7/2022). Issue 7 (18th July 2022)

• Record Type: Journal Article
• Authors: Li, Jin; Chen, Rui; Zheng, Yongjun; Yuan, Weilin; Yang, Tingting; Zhu, Xiaolan; Yan, Yuwei; Jin, Bing; Xu, Wanru; Zhang, Zhongrong; Li, Guoping; Gokulnath, Priyanka; Lei, Zhiyong; Xiao, Junjie
• Is Part Of: Advanced therapeutics. Volume 5:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-18
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202270014
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : In article 2200029, Junjie Xiao and co‐workers construct an artificial circular RNA named circmiR‐29b as a specific molecular sponge for miR‐29b. The artificial circmiR‐29b treat muscle atrophy by suppressing miR‐29b. As shown in the image, skeletal muscle is a super factory that produce protein and ATP. circmiR‐29b mediate as molecular sponge like the powerful magnets which absorb miR‐29b (arrows) and therefore protect the factory from arrows.