A metabolite panel that differentiates Alzheimer's disease from other dementia types. Issue 7 (17th November 2021)

• Record Type: Journal Article
• Authors: Jia, Longfei; Yang, Jianwei; Zhu, Min; Pang, Yana; Wang, Qi; Wei, Qin; Li, Ying; Li, TingTing; Li, Fangyu; Wang, Qigeng; Li, Yan; Wei, Yiping
• Is Part Of: Alzheimer's & dementia. Volume 18:Issue 7(2022)
• Page Start: 1345
• Page End: 1356
• Publication Date: 2021-11-17
• Subjects: Alzheimer's disease -- dementia -- diagnostic model -- metabolite -- neurodegenerative disease; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12484
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites to differentiate AD from other dementias. Methods: Blood metabolites were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential metabolites. Data set 2 (controls, 93; AD, 92) was used to establish a diagnostic AD model with use of a metabolite panel. The model was applied to Data set 3 (controls, 76; AD, 76; other dementias, 205) to verify its capacity for differentiating AD from other dementias. Results: Data set 1 revealed 7 upregulated and 77 downregulated metabolites. In Data set 2, a panel of 11 metabolites was included in a model that could distinguish AD from controls. In Data set 3, this panel was used to successfully differentiate AD from other dementias. Discussion: This study revealed an AD‐specific panel of 11 metabolites that may be used for AD diagnosis.