Analysis of the application value of serum antibody detection for staging of COVID‐19 infection. Issue 2 (13th August 2020)

• Record Type: Journal Article
• Authors: Zheng, Yutong; Yan, Meitian; Wang, Lan; Luan, Liang; Liu, Jing; Tian, Xiao; Wan, Nan
• Other Names: Luo Guangxiang (George) guestEditor.; Ly Hinh guestEditor.; Gao Shou‐Jiang guestEditor.
• Is Part Of: Journal of medical virology. Volume 93:Issue 2(2021)
• Page Start: 899
• Page End: 906
• Publication Date: 2020-08-13
• Subjects: ADE effect -- COVID‐19 -- infection stage -- nucleic acid detection -- SARS‐CoV‐2 -- serum antibody quantitative detection; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.26330
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: Coronavirus disease 2019 (COVID‐19) has now spread all over the world. The National Health Commission of the People's Republic of China reported 78 439 cured and discharged cases, 4634 deaths, 83 462 confirmed cases and 760 818 close contacts as of 25 June 2020. Joint detection of nucleic acids and antibodies has become an important laboratory diagnostic for COVID‐19 patients. Disease progression and infection stage can be established based on the biological characteristics of these tests. However, there have been few studies of the different infection stages of COVID‐19. We conducted a retrospective analysis to explore the clinical characteristics of COVID‐19 patients at different infection stages and to characterize the characteristics of specific serum antibodies at each stage. These pieces of data will provide a theoretical basis for clinical diagnosis and treatment. Highlights: Nucleic acid and antibody were proposed to classify the stages of infection. The effectiveness of the classification method was confirmed by comparing the clinical data of patients at different stages of infection. Rapid and effective classification of infection stages is of great significance for clinical diagnosis and treatment. It is suggested that the disease may be related to the ADE effect, and speculated that the role of antibodies in different stages of the disease is different. It was confirmed that the titer of IgG was related to the severity of the disease.