Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection. (3rd August 2022)

• Record Type: Journal Article
• Authors: Essa, Basma M.; Selim, Adli A.; El-Kawy, O. A.; Abdelaziz, Gamal
• Is Part Of: International journal of radiation biology. Volume 98:Number 8(2022)
• Page Start: 1358
• Page End: 1365
• Publication Date: 2022-08-03
• Subjects: Gallic-AuNPs -- colchicine -- inflammation -- scintigraphy -- 131I-radiolabeling; Radiation -- Physiological effect -- Periodicals; Radiobiology -- Periodicals; 571.45
• DOI: 10.1080/09553002.2022.2047824
• Languages: English
• ISSNs: 0955-3002

Abstract

Abstract: Background: Nanomedicine offers great potential for scintigraphic diagnostic imaging with lower risk and higher quality compared to other traditional techniques. Objectives: This work aimed to develop and evaluate gold nanoparticles combined with gallic acid (gallic-AuNPs) and [ 131 I]iodocolchicine as a scintigraphic probe for inflammation. Methods: [ 131 I]iodocolchicine-gallic-AuNPs were synthesized via chemical reduction method where gallic acid was used as reducing agent and [ 131 I]iodocolchicine was used as stabilizing agent. Then a characteristic profile for the synthesized nano-platform was performed including size analysis, zeta potential, radiochemical yield and in-vivo biodistribution in inflammation bearing mice. Results and Conclusion: This platform was successfully synthesized with good stability, appropriate particle size (10 nm diameter for AuNPs), and high radiochemical purity for [ 131 I]iodocolchicine (96.79%). The in-vivo study indicated that [ 131 I]iodocolchicine-gallic-AuNPs accumulated with a high target to non-target ratio in intravenous injection and high retention value in intra-inflammation injection in inflammation model. The obtained data supported the usefulness of the new platform ([ 131 I]iodocolchicine-gallic-AuNPs) as a tracer for the detection and localization of inflammation.