Unusual morphologic features of low‐grade endometrial stromal sarcoma: A case report. Issue 7 (1st June 2022)

• Record Type: Journal Article
• Authors: Meng, Ling Li; Jia, Xiu Peng; Lu, Li Xia; Zhang, Hui Zhi; Shen, Xiao Han; Piao, Zheng Hua; Ge, Rong; Yu, Wen Ying
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-01
• Subjects: adipocytic differentiation -- endometrial stromal tumours -- rhabdomyoblastic differentiation -- smooth muscle differentiation -- unusual morphologic features; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24502
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: Endometrial stromal tumours are uncommon tumours of the uterus. They mainly occur in perimenopausal women. Tumours with typical clinicopathological features do not usually pose diagnostic problems. However, rare clinicopathological features can occur, and clinicians without significant experience may have difficulty diagnosing these tumours and managing these patients. Methods: Herein, we report a case of endometrial stromal sarcoma that occurred in a 25‐year‐old woman. The pathological features, immunophenotype, treatment and prognosis were discussed. Results: The tumour revealed morphological heterogeneity, and there were similar proliferative‐type endometrial stromal cells, an extensive amount of mature adipose tissue, and prominent rhabdomyoblastic and smooth muscle cells. Histopathological and immunohistochemical studies confirmed low‐grade endometrial stromal sarcoma with smooth muscle, adipocytic and rhabdomyoblastic differentiation (approximately 60% were differentiated tissues). The final treatment of the tumour was total abdominal hysterectomy with bilateral salpingo‐oophorectomy. There was no evidence of recurrence for 109 months postoperatively. Conclusions: We found that low‐grade endometrial stromal tumours with extensive adipocytic and prominent rhabdomyoblastic differentiation are misdiagnosed because they are infrequent. They must be differentiated from rhabdomyosarcoma with accurate identification of adipocytes, and long‐term follow‐up is needed. Abstract : Morphologic features of the low‐grade endometrial stromal sarcoma on haematoxylin–eosin stain. The tumour revealed morphological heterogeneity, there were similar proliferative‐type endometrial stromal cells, an extensive amount of mature adipose tissue, smooth muscle and prominent rhabdomyoblastic cells.