Evaluation of paraffin wax and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) blend patch for tissue engineering. (28th January 2021)

• Record Type: Journal Article
• Authors: Yıldırım, Meryem Akkurt; Demirbilek, Murat; Türkoğlu, Nelisa
• Is Part Of: Materials technology. Volume 36:Number 2(2021)
• Page Start: 105
• Page End: 117
• Publication Date: 2021-01-28
• Subjects: Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) -- paraffin wax -- tissue patch; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2020.1734722
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: In the study, we aimed to develop a multipurpose tissue patch for the repairment of various tissue defects. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was blended with paraffin wax, and the chemical composition of the membranes was determined by the FTIR and RAMAN spectroscopy. The surface area of the PHBHHx and PHBHHx/Paraffin wax were determined as (38, 79 m 2 /g) and (81, 108 m 2 /g), respectively. The DMA and DSC results revealed that blending with paraffin wax, increased the percentage of elongation of the PHBHHx membrane by 7, 6% and reduced the modulus of elasticity. While the elongation at break of PHBHHx tissue patch was 22, 463% (standard error = ± 2, 476), addition of Paraffin wax increased the value to 30, 038% (standard error = ± 7, 228). The antioxidant capacity significantly increased and p53/TP53 levels decreased after blending with paraffin. In conclusion, PHBHHx/paraffin wax blend patches can be considered as a promising biomaterial due to their high cell adhesion capacity depending on its increased surface area, fine anti-oxidant properties, and appropriate mechanical properties.