High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature. Issue 3 (3rd May 2020)

• Record Type: Journal Article
• Authors: Taza, Fadi; Kanwal, Arjun; Zulty, Mary; Mustafa, Sadaf
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 10:Issue 3(2020)
• Page Start: 287
• Page End: 289
• Publication Date: 2020-05-03
• Subjects: Pleomorphic rhabdomyosarcoma -- long-time survival -- primary care and cancer screening -- multimodality treatment -- Chemotherapy; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2020.1766820
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Rhabdomyosarcoma is an aggressive malignant soft-tissue sarcoma that develop from undifferentiated mesenchymal cells. Less than 1% of all adult solid malignant cancers are sarcomas, and RMSs represent less than 2–5% of adult sarcomas. RMS is divided into three main subtypes: Embryonal, alveolar and pleomorphic RMS (PRMS). Most common subtype in adults is PRMS. Most common primary sites are extremities, trunk wall, and genitourinary organs. Metastasis are often found at diagnosis. 5-year overall survival rates were reported in the Surveillance, Epidemiology, and End Results database (SEER) to be 63% for pediatric patients and 27% for adults. Given the rarity of the adult PRMS, variation in its clinical presentation, characteristics of the tumor itself and the prognosis; there are very limited data available to guide the management of adults with PRMS. Herein we present a case report of pleomorphic rhabdomyosarcoma of the right thigh in a 60-year-old male who achieved a long-term survival (30 months) which was accomplished by multimodality treatment including surgery, radiotherapy, and chemotherapy.