Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy. (5th July 2022)

• Record Type: Journal Article
• Authors: Yan, Jiaqi; Zou, Haixia; Zhou, Wenhui; Yuan, Xiaowan; Li, Zhijun; Ma, Xiaodong; Liu, Chang; Wang, Yonghui; Rosenholm, Jessica M.; Cui, Wenguo; Qu, Xiangmeng; Zhang, Hongbo
• Is Part Of: Biomaterials science. Volume 10:Number 15(2022)
• Page Start: 4119
• Page End: 4125
• Publication Date: 2022-07-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d2bm00640e
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Here, cancer targeting hydrogel assembled by the miRNA-21 antisense strand was used to encapsulate mesoporous silica nanoparticles. This toehold mediated strand displacement targeting method can achieve specific drug release and miRNA-21 silencing. Abstract : Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.