Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes. Issue 60 (7th July 2022)

• Record Type: Journal Article
• Authors: Meena, Priyanka; Ayushee, ; Patel, Monika; Verma, Akhilesh K.
• Is Part Of: Chemical communications. Volume 58:Issue 60(2022)
• Page Start: 8424
• Page End: 8427
• Publication Date: 2022-07-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc02781j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described. Abstract : The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. Experimental evidence suggests that the proposed reaction involves the nucleophilic addition of the aminopyridyl radical onto vinyl arenes via a single electron transfer.