A component-optimized chemo-dynamic nanoagent for enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model. (21st June 2022)

• Record Type: Journal Article
• Authors: Qiao, Lihong; Li, Xiaoxia; Xiao, Yuanqiang; Yuan, Jianming; Yu, Dongsheng; Zuo, Mingxiang; Chen, Jifeng; Han, Shisong; Cheng, Du
• Is Part Of: Biomaterials science. Volume 10:Number 15(2022)
• Page Start: 4170
• Page End: 4183
• Publication Date: 2022-06-21
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d2bm00615d
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model. Abstract : Although CuO-deposited bovine serum albumin (CuO-BSA) and glucose oxidase (GOx) were combined to achieve H2 O2 self-supplied chemo-dynamic therapy (CDT) and glucose consumption-based starvation therapy, the uses of copper and GOx have not been optimized to enhance tumour-selective reactive oxygen species (ROS) generation and minimize toxicity to normal cells as well. Here, chemo-dynamic nanoparticles (CBGP NPs) were prepared through a facile biomineralization process and subsequent coatings with GOx and the cationic polymer PEG2k -PEI1.8k . Through optimizing the use of copper, GOx, and PEG2k -PEI1.8k, the CBGP NPs showed high cellular uptake efficiency, enhanced tumour-selective ROS generation, and minimal side effects toward normal cells. The CBGP NP-mediated glucose consumption, GSH-depletion, and ˙OH generation synergistically induced tumour cell apoptosis both in vitro and in vivo . It is believed that the optimized CBGP NPs can be a promising nanoplatform for effective tumour therapy with minimal side effects.