Catalytic N-methyl amidation of carboxylic acids under cooperative conditions. Issue 32 (15th July 2022)

• Record Type: Journal Article
• Authors: Yingxian, Li; Wei, Chen; Linchun, Zhao; Ji-Quan, Zhang; Yonglong, Zhao; Chun, Li; Bing, Guo; Lei, Tang; Yuan-Yong, Yang
• Is Part Of: RSC advances. Volume 12:Issue 32(2022)
• Page Start: 20550
• Page End: 20554
• Publication Date: 2022-07-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra03255d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The generation of N -methyl amides using simple acids with high atom economy is rare owning to the volatile nature of methyl amine. Herein, an atom economic protocol was disclosed to prepare this valuable motif under DABCO/Fe3 O4 cooperative catalysis. Abstract : Amide is a fundamental group that is present in molecular structures of all domains of organic chemistry and the construction of this motif with high atom economy is the focus of the current research. Specifically, N -methyl amides are valuable building blocks in natural products and pharmaceutical science. Due to the volatile nature of methyl amine, the generation of N -methyl amides using simple acids with high atom economy is rare. Herein, we disclose an atom economic protocol to prepare this valuable motif under DABCO/Fe3 O4 cooperative catalysis. This protocol is operationally simple and compatible with a range of aliphatic and (hetero)aromatic acids with very good yields (60–99%). Moreover, the Fe3 O4 can be easily recovered and high efficiency is maintained for up to ten cycles.