Understanding the key functions of Myosins in viral infection. (28th February 2022)

• Record Type: Journal Article
• Authors: He, Jiayi; Qiu, Yixing; Tan, Lei; Duan, Deyong; Yuan, Xiaomin; Yang, Lingchen; Wang, Aibing
• Is Part Of: Biochemical Society transactions. Volume 50:Number 1(2022)
• Page Start: 597
• Page End: 607
• Publication Date: 2022-02-28
• Subjects: host factors -- inhibitors -- molecular mechanisms -- myosins -- viral infection; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20211239
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Myosins, a class of actin-based motor proteins existing in almost any organism, are originally considered only involved in driving muscle contraction, reshaping actin cytoskeleton, and anchoring or transporting cargoes, including protein complexes, organelles, vesicles. However, accumulating evidence reveals that myosins also play vital roles in viral infection, depending on viral species and infection stages. This review systemically summarizes the described various myosins, the performed functions, and the involved mechanisms or molecular pathways during viral infection. Meanwhile, the existing issues are also discussed. Additionally, the important technologies or agents, including siRNA, gene editing, and myosin inhibitors, would facilitate dissecting the actions and mechanisms for described and undescribed myosins, which could be adopted to prevent or control viral infection are also characterized.