Factors associated with hospital admission and severe outcomes for older patients with COVID‐19. Issue 7 (25th February 2022) - Kim, Jiyu
Abstract: Background: Morbidity and death due to coronavirus disease 2019 (COVID‐19) experienced by older adults in nursing homes have been well described, but COVID‐19's impact on community‐living older adults is less studied. Similarly, the previous ambulatory care experience of such patients has rarely been considered in studies of COVID‐19 risks and outcomes. Methods: To investigate the relationship of advanced age (65+), on risk factors associated with COVID‐19 outcomes in community‐living elders, we identified an electronic health records cohort of older patients aged 65+ with laboratory‐confirmed COVID‐19 with and without an ambulatory care visit in the past 24 months ( n = 47, 219) in the New York City (NYC) academic medical institutions and the NYC public hospital system from January 2020 to February 2021. The main outcomes are COVID‐19 hospitalization; severe outcomes/Intensive care unit (ICU), intubation, dialysis, stroke, in‐hospital death), and in‐hospital death. The exposures include demographic characteristics, and those with ambulatory records, comorbidities, frailty, and laboratory results. Results: The 31, 770 patients with an ambulatory history had a median age of 74 years; were 47.4% male, 24.3% non‐Hispanic white, 23.3% non‐Hispanic black, and 18.4% Hispanic. With increasing age, the odds ratios and attributable fractions of sex, race–ethnicity, comorbidities, and biomarkers decreased except for dementia and frailty (Hospital Frailty Risk Score). Patients without ambulatory care histories, compared to those with, had significantly higher adjusted rates of COVID‐19 hospitalization and severe outcomes, with strongest effect in the oldest group. Conclusions: In this cohort of community‐dwelling older adults, we provided evidence of age‐specific risk factors for COVID‐19 hospitalization and severe outcomes. Future research should explore the impact of frailty and dementia in severe COVID‐19 outcomes in community‐living older adults, and the role of engagement in ambulatory care in mitigating severe disease.