Silver Clusters of Five Atoms as Highly Selective Antitumoral Agents Through Irreversible Oxidation of Thiols (Adv. Funct. Mater. 29/2022). (18th July 2022)

• Record Type: Journal Article
• Authors: Porto, Vanesa; Buceta, David; Domínguez, Blanca; Carneiro, Carmen; Borrajo, Erea; Fraile, María; Davila‐Ferreira, Nerea; Arias, Iria R.; Blanco, José M.; Blanco, Maria C.; Devida, Juan M.; Giovanetti, Lisandro J.; Requejo, Félix G.; Hernández‐Garrido, Juan C.; Calvino, José J.; López‐Haro, Miguel; Barone, Giampaolo; James, Andrew M.; García‐Caballero, Tomás; González‐Castaño, Diego M.; Treder, Martin; Huber, Wolfgang; Vidal, Anxo; Murphy, Michael P.; López‐Quintela, M. Arturo; Domínguez, Fernando
• Is Part Of: Advanced functional materials. Volume 32:Number 29(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-18
• Subjects: cancer therapy -- catalysis -- low atomicity clusters -- silver clusters -- sulfur oxidation; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202270166
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Antitumoral Agents In article number 2113028, M. Arturo López‐Quintela, Fernando Domínguez, and co‐workers report that Ag5 clusters show unique catalytic activities to oxidize thiols. They catalyze the complete oxidation of thiols present in cysteine, glutathione, and thioredoxin. This oxidation is tunable by relevant biological oxidants species (hydrogen peroxide and hydroxyl radical), allowing Ag5 to inhibit the thiol‐based antioxidants leading to the selective death of tumor proliferating cells.