DOSE-RATE AND CELL-KILLING SENSITIVITY OF HIGH-LINEAR ENERGY TRANSFER ION BEAM. Issue 1 (19th December 2018)

• Record Type: Journal Article
• Authors: Furusawa, Y; Matsumoto, Y; Hirayama, R; Ohsawa, D; Konishi, T
• Is Part Of: Radiation protection dosimetry. Volume 183:Issue 1/2(2019)
• Page Start: 219
• Page End: 222
• Publication Date: 2018-12-19
• Subjects: Radiation dosimetry -- Periodicals; Radiation -- Safety measures -- Periodicals; 363.1799
• DOI: 10.1093/rpd/ncy267
• Languages: English
• ISSNs: 0144-8420

Abstract

Abstract: It is believed that the dose-rate of radiation will have an influence on cell sensitivity. The dose-rate effects on cell survival can be expressed by the change of the β term in the linear quadratic model. The value at a high-dose-rate decreases below 60 Gy/h and reaches zero at 0.2 Gy/h or less for photons. However, the effect for a high-LET ion-beam is not well known. At HIMAC, cells were exposed to 70 keV/μm carbon-ion beams at different dose-rates between 0.5 and 600 Gy/h at room temperature. The β values for all survival curves show no significant differences among the dose-rates tested for HSG, V79 and CHO cells. Changing the ion-beam dose-rate had no effect on cell survival. This suggests that high-LET particle beams, such as galactic cosmic rays, may not exhibit a dose-rate effect on cell survival. Low-dose-rate radiation showed an effect similar to high-dose-rate radiation.