Dopamine Functionalized Polyethylene Glycol for Improving Stability of Gold Nanoparticles against Reactive Oxygen Species in Serum. Issue 14 (31st March 2022)

• Record Type: Journal Article
• Authors: Kang, Jing; Wu, Fei‐Zheng; Xue, Yao; Li, Zhi‐Han; Wang, Yu‐Xi; Liu, Kun
• Other Names: Mai Yiyong guestEditor.; An Zesheng guestEditor.; Liu Shiyong guestEditor.
• Is Part Of: Macromolecular rapid communications. Volume 43:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-31
• Subjects: antifouling -- dopamine -- oxidative stability -- PEGylated gold nanoparticles -- reactive oxygen species; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202200035
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: PEGylation is the most effective antifouling method for the surface modification of gold nanoparticles (AuNPs). However, thiol‐terminated polyethylene glycol (PEG) ligands tethered on the AuNPs are instable in serum and can detach from the AuNP surface, resulting in a significant reduce of their antifouling properties. Herein, it is reported that reactive oxygen species (ROS) is a major factor causing the detachment of PEG ligands from AuNP surfaces. By covalently backfilling dopamine‐functionalized PEG on the AuNPs, the stability of PEG ligands on AuNP surface and the antifouling ability of AuNPs can be effectively improved. Tuning the balance between ROS and dopamine‐functionalized PEG can be used as a new strategy to control the self‐assembly of AuNPs and serum proteins. Abstract : The reactive oxygen species (ROS) in serum is a major factor for the detachment of thiol‐terminated polyethylene glycol (HS‐PEG) ligands on gold nanoparticles (AuNPs). By covalently backfilling dopamine‐functionalized PEG on AuNPs to trap ROS, the stability of HS‐PEG ligands on AuNPs and antifouling ability of AuNPs can be effectively improved.