Atrial septal defect in adulthood: a new paradigm for congenital heart disease. (18th September 2021)

• Record Type: Journal Article
• Authors: Brida, Margarita; Chessa, Massimo; Celermajer, David; Li, Wei; Geva, Tal; Khairy, Paul; Griselli, Massimo; Baumgartner, Helmut; Gatzoulis, Michael A
• Is Part Of: European heart journal. Volume 43:Number 28(2022)
• Page Start: 2660
• Page End: 2671
• Publication Date: 2021-09-18
• Subjects: Atrial septal defect -- Sinus venosus defect -- Device closure -- Atrial septal defect surgery -- Advanced imaging -- Pulmonary arterial hypertension; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; 616.12005
• DOI: 10.1093/eurheartj/ehab646
• Languages: English
• ISSNs: 0195-668X

Abstract

Abstract: Atrial septal defects (ASDs) represent the most common congenital heart defect diagnosed in adulthood. Although considered a simple defect, challenges in optimal diagnostic and treatment options still exist due to great heterogeneity in terms of anatomy and time-related complications primarily arrhythmias, thromboembolism, right heart failure and, in a subset of patients, pulmonary arterial hypertension (PAH). Atrial septal defects call for tertiary expertise where all options may be considered, namely catheter vs. surgical closure, consideration of pre-closure ablation for patients with atrial tachycardia and suitability for closure or/and targeted therapy for patients with PAH. This review serves to update the clinician on the latest evidence, the nuances of optimal diagnostics, treatment options, and long-term follow-up care for patients with an ASD. Graphical Abstract: