Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening. Issue 7 (17th March 2022)

• Record Type: Journal Article
• Authors: Tagny, Claude T.; Ikomey, Georges; Ngo Sack, Françoise; Achu, Celestin; Ndemanou, Matthias; Ninmou, Catherine; Gesu, Caroline; Essomba, Gilbert; Fongue Simo, Alexandra; Nguefack Tsague, Georges; Mbanya, Dora; Murphy, Edward
• Is Part Of: Vox sanguinis. Volume 117:Issue 7(2022)
• Page Start: 920
• Page End: 928
• Publication Date: 2022-03-17
• Subjects: Africa -- blood safety -- donor health questionnaire -- HIV; Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.13270
• Languages: English
• ISSNs: 0042-9007

Abstract

Abstract: Background and Objectives: We had previously developed an Africa‐specific donor health questionnaire (ASDHQ) based on local risk factors and designed a scoring scheme. This study assessed the performance of a new donor health questionnaire by comparing the human immunodeficiency virus (HIV) status in accepted versus deferred donors by ASDHQ and comparing the rate of risk deferrals with historical data. Materials and Methods: Data were collected during a cross‐sectional study conducted over 15 months at three referral‐hospital‐based blood services in Cameroon. ASDHQ was administered to blood donors aged 18–65 years in the same screening conditions as the routine questionnaire. The main outcomes of the study were ASDHQ sensitivity and specificity with regard to HIV laboratory testing as well as donor deferral rates for each of the routine screening algorithms and for ASDHQ. Results: Overall, 71/11, 120 (0.6%) were confirmed as HIV positive. The mean ASDHQ score was 95.80 ± 4.4 in HIV‐negative donors and 94.80 ± 4.4 in HIV‐positive donors ( p = 0.05). The optimal cut‐off provided by the receiver operating characteristic (ROC) curve for the best performance of ASDHQ was 95.04. Using this optimal cut‐off, the ASDHQ sensitivity and specificity were 57% and 53%, respectively (area under curve = 0.58 [0.51, 0.64], p = 0.028). Using ASDHQ, the HIV prevalence was 0.7% in deferred donors and 0.6% in accepted donors. Conclusion: ASDHQ might be efficient only in specific conditions that maximize truthful donor responses, requiring each blood service to create an environment of trust and transparency to increase donor compliance and improve the accuracy of the questionnaire.