Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight. Issue 14 (15th July 2022)

• Record Type: Journal Article
• Authors: Othman, Ahmed; Amen, Yhiya; Matsumoto, Masako; Nagata, Maki; Shimizu, Kuniyoshi
• Is Part Of: Natural product research. Volume 36:Issue 14(2022)
• Page Start: 3610
• Page End: 3618
• Publication Date: 2022-07-15
• Subjects: Alkaloids -- lignanamides -- Bassia indica -- Chenopodiaceae -- halophytes -- anticholinesterase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1872572
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: N -[(3-(3-methyl-1-oxo-butyl)amino)propyl]-3-(3, 4-dihydroxyphenyl)prop-2-enamide (7 ), named 'Bassiamide A', a new alkaloid, together with six known compounds including one lignan (1 ) and five lignanamides (2–6 ), were isolated from the aerial parts of Bassia indica Wight. The study also reported an optimal separation of a rare occurring R -isomer lignanamide derivative (6 ) from a natural origin, in addition to its known corresponding S -isomer (5 ). Structures of isolated compounds were elucidated based on NMR spectroscopic data, HR-MS, and comparison with known related ones, and they were identified as syringaresinol (1 ), N - trans -feruloyl-3-methoxytyramine (2 ), N - trans -feruloyltyramine (3 ), S -(-)- N - trans -feruloyl normetanephrine (4 ), S -(-)- N - trans -feruloyl octopamine (5 ), R -(+)- N - trans -feruloyl octopamine (6 ). The isolated compounds were evaluated for their anti-acetylcholinesterase activity, and they showed weak inhibitory activity. Graphical Abstract: UF0001