Reticulatin, a novel C43-spiroterpenoid from the lichen Parmotrema reticulatum growing in Vietnam. Issue 14 (15th July 2022)

• Record Type: Journal Article
• Authors: Duong, Thuc-Huy; Nguyen, Van-Kieu; Sichaem, Jirapast; Tran, Thanh-Nha; Do, Thanh-Hung; Pham, Nguyen-Kim-Tuyen; Nguyen, Thi-Anh-Tuyet; Nguyen, Thi-Hoai-Thu; Mai, Dinh-Tri; Nguyen, Ngoc-Hong; Huynh, Bui-Linh-Chi
• Is Part Of: Natural product research. Volume 36:Issue 14(2022)
• Page Start: 3705
• Page End: 3712
• Publication Date: 2022-07-15
• Subjects: Parmeliaceae -- Parmotrema reticulatum -- Lichen -- C43-spiroterpenoid -- γ-lactone -- reticulatin -- α-glucosidase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1885032
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A novel C43 -spiroterpenoid, reticulatin (1 ), was isolated from the lichen Parmotrema reticulatum (Taylor) M. Choisy (Parmeliaceae). Five previously-reported compounds were also isolated: zeorin (2 ), leucotylin (3 ), lupeol (4 ), betulinic acid (5 ), and dihydroreynosin (6 ). The structures were elucidated by 1D, 2D NMR, and HRESIMS spectroscopy and comparison with the literature. We propose that reticulatin is a biosynthetic product of fusicoccadiene and vinapraesorediosic acid A via Diels-Alder addition. Reticulatin is the first C43 -spiroterpenoid identified from lichen metabolites. All compounds were evaluated for inhibition of α- glucosidase. Compound 1 showed the most potent inhibition, with an IC50 value of 3.90 μM, much lower than that of the acarbose positive control (IC50 165 µM). Graphical Abstract: UF0001