Spanish National Registry of Paediatric Coeliac Disease: Changes in the Clinical Presentation in the 21st Century. Issue 6 (2nd June 2022)

• Record Type: Journal Article
• Authors: Solís, David Pérez; Pascual, Ma Luz Cilleruelo; Sangrador, Carlos Ochoa; Burriel, Jose Ignacio García; Visus, Félix Sánchez-Valverde; Arocena, Francisco Javier Eizaguirre; Calatayud, Salvador Garcia; Nodal, Eva Martinez-Ojinaga; Aliaga, Ester Donat; Torres, Josefa Barrio; Villasante, Gemma Castillejo de; Cid, Ma del Carmen Miranda; Peral, Ricardo Torres; Lopez, Raquel Vecino; Ruiz, Mercedes Juste; Ramos, Honorio Armas; Garcia, Patricia Barros; Leis, Rosaura; Alberdi, Rosa Solaguren; Quero, José Carlos Salazar; GarciaRomero, Ruth; Clastillo, Luis Ortigosa del; Quintana, Luis Peña; Telleria, Pedro Urruzuno; Franch, Pilar Codoñer; Casales, Zuriñe Garcia; Mas, Maria Lluïsa Masiques; Poblet, Gonzalo Galicia; Costa, Cecilia Martinez; Serrano, Elena Balmaseda; Allué, Isabel Polanco; Koninck, Carmen Ribes; Riechmann, Enriqueta Román;
• Other Names: collaborator.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 74:Issue 6(2022)
• Page Start: 805
• Page End: 811
• Publication Date: 2022-06-02
• Subjects: children -- coeliac disease -- diagnosis -- epidemiology -- Europe; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000003424
• Languages: English
• ISSNs: 0277-2116

Abstract

ABSTRACT: Objectives: Over the last several decades, there has been a tendency towards a predominance of less symptomatic forms of coeliac disease (CD) and an increase in the patient age at diagnosis. This study aimed to assess the clinical presentation and diagnostic process of paediatric CD in Spain. Methods: A nationwide prospective, observational, multicentre registry of new paediatric CD cases was conducted from January 2011 to June 2017. The data regarding demographic variables, type of birth, breast-feeding history, family history of CD, symptoms, height and weight, associated conditions, serological markers, human leukocyte antigen (HLA) phenotype, and histopathological findings were collected. Results: In total, 4838 cases (61% girls) from 73 centres were registered. The median age at diagnosis was 4 years. Gastrointestinal symptoms were detected in 71.4% of the patients, and diarrhoea was the most frequent symptom (45.9%). The most common clinical presentation was the classical form (65.1%) whereas 9.8% ofthe patients were asymptomatic. There was a trend towards an increase in the age at diagnosis, proportion of asymptomatic CD cases, and usage of anti-deamidated gliadin peptide antibodies and HLA typing for CD diagnosis. There was, however, a decreasing trend in the proportion of patients undergoing biopsies. Some of these significant trend changes may reflect the effects of the 2012 ESPGHAN diagnosis guidelines. Conclusions: Paediatric CD in Spain is evolving in the same direction as in the rest of Europe, although classical CD remains the most common presentation form, and the age at diagnosis remains relatively low.