Detection of high levels of resistance to linezolid and vancomycin inStaphylococcus aureus. Issue 9 (September 2017)

• Record Type: Journal Article
• Authors: Azhar, Aysha; Rasool, Samreen; Haque, Asma; Shan, Sidra; Saeed, Muhammad; Ehsan, Beenish; Haque, Abdul
• Is Part Of: Journal of medical microbiology. Volume 66:Issue 9(2017)
• Publication Date: 2017-09
• Subjects: S. aureus -- linezolid -- vancomycin; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmm.0.000566
• Languages: English
• ISSNs: 0022-2615

Abstract

Abstract : Abstract : Both methicillin‐resistant Staphylococcus aureus (MRSA) and methicillin‐sensitive S. aureus (MSSA) are rapidly overcoming the current array of drugs. One hundred and fifty isolates from a hospital were studied for resistance towards linezolid and vancomycin. Fifty‐four (36.0%) isolates were MRSA. Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2%, respectively. The figures for the E‐test were 46.3 and 27.0%, respectively. The vancomycin resistance was remarkable in MRSA (14.8%), but relatively low in MSSA (3.1%). The E‐test results were 13.0 and 4.16%, respectively. The cfr gene was detected in 78% of linezolid‐resistant isolates and the vanA operon was detected in 74% of vancomycin‐resistant isolates. This level of resistance against linezolid and vancomycin is unprecedented. These results are alarming and highlight the threat of non‐treatable S. aureus strains.