Long-term HIV treatment outcomes and associated factors in sub-Saharan Africa: multicountry longitudinal cohort analysis. (1st August 2022)

• Record Type: Journal Article
• Authors: Inzaule, Seth C.; Kroeze, Stefanie; Kityo, Cissy M.; Siwale, Margaret; Akanmu, Sulaimon; Wellington, Maureen; de Jager, Marleen; Ive, Prudence; Mandaliya, Kishor; Stevens, Wendy; Steegen, Kim; Nankya, Immaculate; Boender, T. Sonia; Ondoa, Pascale; Sigaloff, Kim C.E.; de Wit, Tobias F. Rinke; Hamers, Raph L.
• Is Part Of: AIDS. Volume 36:Number 10(2022)
• Page Start: 1437
• Page End: 1447
• Publication Date: 2022-08-01
• Subjects: HIV drug resistance -- immune response -- long-term treatment outcomes -- retention -- sub-Saharan Africa -- viral suppression; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000003270
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : Objective: In a multicountry prospective cohort of persons with HIV from six countries between 2007 and 2015, we evaluated long-term outcomes of first-line non-nucleoside reverse-transcriptase inhibitor-based antiretroviral therapy (ART), and risk factors for loss-to-follow-up, mortality, virological failure, and incomplete CD4 + T-cell recovery. Methods: We calculated cumulative incidence of lost-to-follow-up, death, virological failure (VL ≥ 1000 cps/ml) and incomplete CD4 + T-cell recovery (<500 cells/μl) at successive years, using Kaplan–Meier and Cox regression. Results: Of 2735 participants, 58.0% were female, median age was 37 (interquartile range [IQR] 32–43) years, and median pre-ART CD4 + T-cell count was 135 (IQR 63–205)/μl. Total follow-up time was 7208 person-years (median 24.3 months, IQR 18.7–58.3). Deaths by any cause and loss to follow-up occurred mostly during the first year of ART (84%, 201/240 and 56%, 199/353, respectively). During their first 6 years of ART, 71% (95% confidence interval [CI] 69.0–73.7) were retained on first-line, and among those 90–93% sustained viral suppression (<1000 cps/ml); CD4 + T-cell recovery was incomplete in 60% (220/363) of participants. The risk factors associated with poor outcomes during long-term ART were: for loss-to-follow-up, recent VL ≥1000 cps/ml, recent CD4 + T-cell count ≤50 cells/μl, age <30 years, being underweight; for mortality, recent CD4 + T-cell count ≤50 cells/μl; and, for virological failure, age <40 years, recent CD4 + T-cell count ≤200 cells/μl, poor adherence, male sex, and low-level viremia. Conclusion: To achieve long-term ART success towards the UNAIDS targets, early ART initiation is crucial, coupled with careful monitoring and retention support, particularly in the first year of ART. Male and youth-centred care delivery models are needed to improve outcomes for those vulnerable groups.