Calcium and phosphorus co-doped carbon dots enhance osteogenic differentiation for calvarial defect repair in situ. (1st September 2022)

• Record Type: Journal Article
• Authors: Wu, Lin; Wu, Yunchao; Jingjin, Liu; Liu, Suwan; Li, Qianzhe; Yang, Mengyu; Zhang, Miaomiao; Ji, Qing; Zhang, Feimin; Du, Fengyi
• Is Part Of: Biomedical materials. Volume 17:Number 5(2022)
• Publication Date: 2022-09-01
• Subjects: carbon dots -- calcium -- phosphorus -- calvarial defect; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/ac812f
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: Calvarial bone defect remains a clinical challenge due to the lack of efficient osteo-inductive agent. Herein, a novel calcium and phosphorus codoped carbon dot (Ca/P-CD) for bone regeneration was synthesized using phosphoethanolamine and calcium gluconate as precursors. The resultant Ca/P-CDs exhibited ultra-small size, stable excitation dependent emission spectra and favorable dispersibility in water. Moreover, Ca/P-CDs with good biocompatibility rapidly entered the cytoplasm through endocytosis and increased the expression of bone differentiation genes. After mixing with temperature-sensitive hydrogel, Ca/P-CDs were injected in situ into calvarial defect and promoted the repair of bone injury. These Ca/P-CDs provide a new treatment method for the bone repair and should be expended the application in the biomedical fields.