Degradable poly(catechin) nanoparticles as a versatile therapeutic agent. Issue 14 (22nd September 2022)

• Record Type: Journal Article
• Authors: Suner, Selin S.; Sahiner, Mehtap; Mohapatra, Subhra; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Sahiner, Nurettin
• Is Part Of: International journal of polymeric materials. Volume 71:Issue 14(2022)
• Page Start: 1104
• Page End: 1115
• Publication Date: 2022-09-22
• Subjects: Catechin -- CAT nanoparticles -- antioxidant -- cancer therapy -- metal chelating -- antidiabetic; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2021.1941957
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 ± 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 °C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 µg/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 ± 7 and 456 ± 54 µg/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 ± 0.8 µmol/g Trolox equivalent antioxidant capacity by 2, 2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS + ) scavenging assay. Graphical Abstract: UF0001