A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcation. (August 2022)

• Record Type: Journal Article
• Authors: Amine, Saida; Hajri, Youssra; Allali, Karam
• Is Part Of: Chaos, solitons and fractals. Volume 161(2022)
• Publication Date: 2022-08
• Subjects: Cancer treatment -- Virotherapy -- Two delays -- Immune response -- Local stability -- Hopf bifurcation; Chaotic behavior in systems -- Periodicals; Solitons -- Periodicals; Fractals -- Periodicals; Chaotic behavior in systems; Fractals; Solitons; Periodicals; 003.7
• DOI: 10.1016/j.chaos.2022.112396
• Languages: English
• ISSNs: 0960-0779

Abstract

Abstract: A fractional-order tumor virotherapy model with two time delays is presented and analyzed in this paper. The existence, positivity and bounbdedness of solutions under positive initial conditions will be proved. The basic reproduction number R 0 and the immune response reproduction number R 1 are given. The virus-free equilibrium E 0 and the therapy partial success equilibrium E ∗ are presented depending on the value of R 0 and R 1 . Sufficient conditions to ensure the local stability of both the virus-free equilibrium and the therapy partial success equilibrium according to different values of two time delays are established. By considering the time delay as a bifurcation parameter, it was appeared that the model undergoes a Hopf bifurcation when the delay passes through a critical value. Finally, numerical simulations were carried out to support the theoretical results and to show the effect of both the fractional-order derivative and the time delays. Highlights: A fractional-order tumor virotherapy model with two time delays is presented and studied. The existence, positivity and boundedness of solutions are proved. The local stability of both the virus-free equilibrium and the therapy partial success equilibrium is established. Hopf bifurcation is observed when the delay passes through a critical value. Numerical simulations were carried out to support the theoretical results.