Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities. (September 2022)

• Record Type: Journal Article
• Authors: Song, Min; Chan, Ging; Lin, Li-Gen; Li, Derong; Zhang, Kehan; Zhang, Xiao-Qi; Ye, Wen-Cai; Li, Na; Zhang, Qing-Wen
• Is Part Of: Phytochemistry. Volume 201(2022)
• Publication Date: 2022-09
• Subjects: Melia azedarach L. -- Meliaceae -- Tetracyclic triterpenoids -- Cytotoxicity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113280
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eleven undescribed tetracyclic triterpenoids, meliazedarachins A–K, along with twenty-six known compounds were isolated from the fruits of Melia azedarach L.. Their structures were determined by HRESIMS, UV, IR, NMR, X-ray diffraction, electronic circular dichroism (ECD) spectra, and the modified Mosher's method. The cytotoxic activities of all the isolates were measured. Meliazedarachin K and mesendanin N showed cytotoxicity against five human cancer cell lines with IC50 values ranging from 9.02 to 31.31 μ M. Meliazedarachin K showed significant cytotoxicity against HCT116 cell line with IC50 value of 9.02 ± 0.84 μ M. 21 α -methylmelianodiol showed significant cytotoxicity against HCT116 and RKO cell lines with IC50 values of 10.16 ± 1.22 and 8.57 ± 0.80 μ M, respectively. Graphical abstract: Eleven undescribed tetracyclic triterpenoids, meliazedarachins A–K, along with twenty-six known compounds were isolated from the fruits of Melia Azedarach L. Image 1 Highlights: Eleven undescribed tetracyclic triterpenoids were isolated and identified from the fruits of Melia azedarach L.. Their structures were determined by HRESIMS, UV, IR, NMR, X-ray diffraction, ECD, and the modified Mosher's method. Some compounds showed significant cytotoxicity against human cancer cell lines.