Pyridine hydrochloride-promoted CC bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives. (3rd August 2022)

• Record Type: Journal Article
• Authors: Liu, Aqin; Li, Yanwu; Zhang, Xiuyu; Kuang, Qiulin; Li, Suzhen; Liao, Siwei; Huang, Xin; Wang, Yin; Xu, Ping; Wu, Huili; Guo, Mengyi; Ma, Wanqian; Song, Yibo; Hu, Xueyuan; Yuan, Jianyong
• Is Part Of: Tetrahedron letters. Volume 103(2022)
• Publication Date: 2022-08-03
• Subjects: Pyridine hydrochloride -- Acylation -- Anilines -- 1, 3-diketones -- CC cleavage; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153967
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: This article reports an efficient method for the synthesis of amide derivatives by the direct reactions of aromatic amines with 1, 3-diketones promoted by pyridine hydrochloride under metal-free and solvent-free conditions. This transformation was accomplished by cleavage of CC bond in the presence of pyridine hydrochloride as additive, which excludes the use of transition-metals and harsh reaction conditions. This method has a broad substrate scope and good tolerance for sensitive functional groups. A multi-gram scale reaction is also performed to ensure the scalability of the reaction.