Epidemiologic evaluation of clinical outcomes in ethnic minorities with myelodysplastic syndromes. (August 2022)

• Record Type: Journal Article
• Authors: Molina, Alfonso; Xiao, Lan; Ostrom, Quinn T.; Rosas, Lisa G.; Greenberg, Peter L.
• Is Part Of: Leukemia research. Volume 119(2022)
• Publication Date: 2022-08
• Subjects: Myelodysplastic syndromes -- Healthcare disparities -- Sociodemographic factors; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2022.106907
• Languages: English
• ISSNs: 0145-2126

Abstract

Abstract: Since race/ethnicity and socioeconomic status (SES), including economic and educational disadvantage (EED), may impact overall survival (OS) in primary myelodysplastic syndromes (MDS), we analyzed the impact of these characteristics on OS in Non-Hispanic White (NHW), Non-Hispanic Black (NHB) and Hispanic patients. In this retrospective review using the SEER US population and American Community Survey data between 2001 and 2016, factor analysis was used for 23 county-level SES indicators to identify groups of interrelated measures of EED. For the 52, 739 patients identified, increased age at diagnosis, male sex, higher prognostic risk category and higher EED were all associated with reduced OS. The most prominent SES factor extracted by factor analysis was EED. NHB patients had the highest OS compared to NHW and Hispanics. For all patients, EED analysis showed lower OS for most compared to least disadvantaged, most notably in lower-risk disease and Hispanics. More NHB and Hispanics (51% and 49%) were in the most disadvantaged category compared with NHW (30%). No significant differences were noted for causes of death by race/ethnicity. In conclusion, these data indicate that in addition to standard clinical measures for analyzing OS, race/ethnicity, SES and EED are critical determinants for assessing clinical outcomes in MDS patients. Highlights: Race/ethnicity are important factors associated with overall survival (OS) in MDS. Non-Hispanic Blacks had longer OS vs Non-Hispanic Whites or Hispanic patients. Economic and Educational Disadvantage (EED) was associated with lower OS in MDS. Impact of EED was most notable in lower-risk MDS and Hispanic patients.