High incidence of epileptiform activity in adults undergoing extracorporeal membrane oxygenation. (August 2022)

• Record Type: Journal Article
• Authors: Amorim, Edilberto; Firme, Marcos S.; Zheng, Wei-Long; Shelton, Kenneth T.; Akeju, Oluwaseun; Cudemus, Gaston; Yuval, Raz; Westover, M Brandon
• Is Part Of: Clinical neurophysiology. Volume 140(2022)
• Page Start: 4
• Page End: 11
• Publication Date: 2022-08
• Subjects: EEG -- ECMO -- Extracorporeal membrane oxygenation -- Stroke -- Critical care; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.04.018
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Near two thirds of subjects undergoing ECMO in this cohort had epileptiform or ictal-interictal continuum abnormalities on EEG. Nonconvulsive status epilepticus was infrequent (3%) for subjects undergoing ECMO support. Acute neuroimaging findings were not associated with epileptiform abnormalities in subjects undergoing ECMO support. Abstract: Objective: The prevalence of seizures and other types of epileptiform brain activity in patients undergoing extracorporeal membrane oxygenation (ECMO) is unknown. We aimed to estimate the prevalence of seizures and ictal-interictal continuum patterns in patients undergoing electroencephalography (EEG) during ECMO. Methods: Retrospective review of a prospective ECMO registry from 2011-2018 in a university-affiliated academic hospital. Adult subjects who had decreased level of consciousness and underwent EEG monitoring for seizure screening were included. EEG classification followed the American Clinical Neurophysiology Society criteria. Poor neurological outcome was defined as a Cerebral Performance Category of 3–5 at hospital discharge. Results: Three hundred and ninety-five subjects had ECMO, and one hundred and thirteen (28.6%) had EEG monitoring. Ninety-two (23.3%) subjects had EEG performed during ECMO and were included in the study (average EEG duration 54 h). Veno-arterial ECMO was the most common cannulation strategy (83%) and 26 (28%) subjects had extracorporeal cardiopulmonary resuscitation. Fifty-eight subjects (63%) had epileptiform activity or ictal-interictal continuum patterns on EEG, including three (3%) subjects with nonconvulsive status epilepticus, 33 (36%) generalized periodic discharges, and 4 (5%) lateralized periodic discharges. Comparison between subjects with or without epileptiform activity showed comparable in-hospital mortality (57% vs. 47%, p = 0.38) and poor neurological outcome (and 56% and 36%, p = 0.23). Twenty-seven subjects (33%) had acute neuroimaging abnormalities (stroke N = 21). Conclusions: Seizures and ictal-interictal continuum patterns are commonly observed in patients managed with ECMO. Further studies are needed to evaluate whether epileptiform activity is an actionable target for interventions. Significance: Epileptiform and ictal-interictal continuum abnormalities are frequently observed in patients supported with ECMO undergoing EEG monitoring.