Effects of a ketogenic diet in women with PCOS with different uric acid concentrations: a prospective cohort study. Issue 2 (August 2022)

• Record Type: Journal Article
• Authors: Yang, Mukun; Bai, Wenpei; Jiang, Bo; Wang, Zijun; Wang, Xiaoxue; Sun, Yu; Liu, Feiran; Cui, Guangxia; Song, Xiaohong; Li, Jian; Wu, Fengyun
• Is Part Of: Reproductive biomedicine online. Volume 45:Issue 2(2022)
• Page Start: 391
• Page End: 400
• Publication Date: 2022-08
• Subjects: Amenorrhoea -- Body weight -- Hyperuricaemia -- Ketogenic diet -- Polycystic ovary syndrome; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2022.03.023
• Languages: English
• ISSNs: 1472-6483

Abstract

Highlights: A ketogenic diet intervention is beneficial for overweight/obese women with PCOS Uric acid concentrations may affect weight loss during ketogenic diet interventions With weight loss, some women with PCOS can resume menstruation Abstract: Research question: Do overweight/obese women with PCOS with different uric acid concentrations show different effects after a ketogenic diet intervention? Design: The study involved women with PCOS with a body mass index (BMI) of ≥24 kg/m 2 . Groups showing different uric acid concentrations were given ketogenic diet guidance for 12 weeks. Weight, BMI, body fat percentage, fasting blood glucose, triacylglyerols, total cholesterol, uric acid and other metabolism-related indexes were measured. Results: After 12 weeks of the ketogenic diet intervention, body weight (hyperuricaemia group: P= 0.001; non-hyperuricaemia group: P <0.001), BMI (hyperuricaemia group: P = 0.025; non-hyperuricaemia group: P <0.001) and body fat percentage (hyperuricaemia group: P <0.001; non-hyperuricaemia group: P <0.001) were decreased in both groups. There was greater weight loss in the non-hyperuricaemia group (hyperuricaemia group 11.2±4.6 kg versus non-hyperuricaemia group 14.7±4.8 kg; P < 0.05). In the non-hyperuricaemia group, uric acid concentrations increased significantly after 6 weeks of the ketogenic diet intervention (week 0: 5.69±0.84 mg/dl versus week 6: 8.41 ± 2.33 mg/dl; P < 0.001) and reached the concentrations of the hyperuricaemia group (week 6: 9.37 ± 2.43 mg/dl; P > 0.05). Conclusions: A ketogenic diet intervention is beneficial for overweight/obese women with PCOS with different serum uric acid concentrations. Participants with normal basal uric acid concentrations showed a greater fluctuation of serum uric acid concentrations during the ketogenic diet intervention and had a greater weight loss.