An Fe-based single-atom nanozyme with multi-enzyme activity for parallel catalytic therapy via a cascade reaction. Issue 57 (28th June 2022)

• Record Type: Journal Article
• Authors: Niu, Rui; Liu, Yang; Wang, Yinghui; Zhang, Hongjie
• Is Part Of: Chemical communications. Volume 58:Issue 57(2022)
• Page Start: 7924
• Page End: 7927
• Publication Date: 2022-06-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc02975h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Fe-based single-atom nanozymes with multi-enzyme activities and excellent photothermal properties were synthesized for highly efficient parallel catalytic therapy and photothermal therapy. Abstract : Here, we report Fe-based single-atom nanozymes, which were fabricated by embedding Fe atoms into N-doped hollow carbon spheres. The nanozymes (FeSA-HNCSB) exhibit the efficient catalytic generation of ROS in the tumor microenvironment (TME). They possess multiple enzyme-mimicking activities, including catalase-like, oxidase-like, and peroxidase-like activities. Furthermore, the FeSA-HNCSB nanozymes also exhibit good photothermal conversion efficiency in the near-infrared (NIR) region, making them potential candidates for photothermal therapy (PTT) and photothermal-enhanced catalytic therapy. This work provides a new paradigm for integrating parallel catalytic therapy and PTT to improve the effectiveness of tumor treatment.