Routine preoperative brain CT in resectable non-small cell lung cancer – Ten years experience from a tertiary UK thoracic center. (August 2018)

• Record Type: Journal Article
• Authors: Matys, Tomasz; Drury, Rosalyn; David, Sarojini; Rassl, Doris M.; Qian, Wendi; Rintoul, Robert C.; Screaton, Nicholas J.
• Is Part Of: Lung cancer. Volume 122(2018)
• Page Start: 195
• Page End: 199
• Publication Date: 2018-08
• Subjects: NSCLC non-small cell lung carcinoma -- SCC squamous cell carcinoma -- AC adenocarcinoma -- NOS non-otherwise specified -- CE-CT contrast-enhanced CT -- MRI magnetic resonance imaging; Non-small cell lung carcinoma -- Computed tomography -- Brain metastasis -- Staging; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2018.06.014
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: 2% of patients with NSCLC have brain metastases on brain CT at staging. the majority of these metastases are asymptomatic and would be undetected. brain CT can be useful in routine staging of non-small cell lung cancer. Abstract: Objectives: Although detection of brain metastasis can change treatment intent in non-small cell lung carcinoma (NSCLC), head imaging is not routinely performed during initial staging. In our previous study, 4.8% of patients considered for surgical treatment had asymptomatic synchronous brain metastases, encouraging us to include contrast-enhanced head CT (CE-CT) in our routine staging protocol. We present results from a large cohort of potentially resectable NSCLC patients imaged irrespective of the presence of neurological symptoms. Materials and Methods: Patients with newly diagnosed NSCLC were identified from Royal Papworth Hospital registries. Data regarding the clinical stage (7th edition TNM), neurological symptoms and imaging findings were retrieved from clinical records. Results: 1074 NSCLC patients considered potentially resectable based on the initial staging CT of the chest and abdomen (stage IA-IIIB) were included. Synchronous brain metastases were detected by CE-CT in 23 patients (2.1%); the rate of positive findings increased with stage, ranging from 0.7% (IA) to 2.6% (IIIA) (p = 0.023). The majority of metastases were asymptomatic (19 of 23, 82.6%). Asymptomatic brain lesions were smaller than symptomatic (13.3 ± 4.8 vs 24.8 ± 8.2 mm; p < 0.01); in both groups, the most frequent location was frontal lobe. Conclusion: Routine CE-CT detected synchronous brain metastases in approximately 2% of NSCLC patients eligible for radical surgical treatment. The majority of the metastatic lesions were asymptomatic. With the exception of stage IA in which the detection rate is very low, CE-CT could therefore be useful in routine NSCLC staging.