Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in glioblastoma. (September 2020)

• Record Type: Journal Article
• Authors: Windisch, Paul; Röhrich, Manuel; Regnery, Sebastian; Tonndorf-Martini, Eric; Held, Thomas; Lang, Kristin; Bernhardt, Denise; Rieken, Stefan; Giesel, Frederik; Haberkorn, Uwe; Debus, Jürgen; Adeberg, Sebastian
• Is Part Of: Radiotherapy and oncology. Volume 150(2020)
• Page Start: 159
• Page End: 163
• Publication Date: 2020-09
• Subjects: Brain neoplasms -- Radiotherapy -- Positron emission tomography computed tomography -- Glioblastoma -- Fibroblasts; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2020.06.040
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: In an analysis of 13 patients who underwent both, FAP-specific PET and MRI, the resulting volumes were incongruent. No complications occurred during either MRI or FAP-specific PET. FAP-specific PET provides additional information for radiotherapy planning and might prove useful for biopsy planning given the heterogeneous tracer enhancement. Abstract: Fibroblast Activation Protein (FAP)-specific Positron Emission Tomography (PET) has shown promising results in various cancers. This pilot study compares FAP-specific PET to MRI for treatment planning in 13 Glioblastoma patients. The resulting incongruent volumes could provide additional information for radiotherapy or biopsy planning.