Chain-shattering polymeric sulfur dioxide prodrug micelles for redox-triggered gas therapy of osteosarcoma. Issue 27 (28th June 2022)

• Record Type: Journal Article
• Authors: Liu, Peng; Zhang, Weifei; Deng, Jiapeng; Zheng, Yien; Weng, Jian; Yu, Fei; Wang, Deli; Zheng, Ming; Kang, Bin; Zeng, Hui
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 27(2022)
• Page Start: 5263
• Page End: 5271
• Publication Date: 2022-06-28
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb00287f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A chain-shattering polymeric SO2 prodrug micelle system was fabricated for effective SO2 delivery and redox-triggered SO2 based gas therapy of osteosarcoma. Abstract : Sulfur dioxide (SO2 ) based gas therapy has received great attention recently. Nevertheless, it is still a challenge to fabricate a SO2 delivery system to achieve effective delivery and on-demand stimuli triggered release at tumor sites. Herein, a chain-shattering polymeric SO2 prodrug micelle system was fabricated for effective SO2 based gas therapy. First, an amphiphilic polymer (mPEG-P(HDI-DN)) was prepared by polycondensation of poly(ethylene glycol) methyl ether, hexamethylene diisocyanate and monomer containing SO2 . mPEG-P(HDI-DN) can self-assemble into spherical micelles with a diameter of around 50–90 nm. Triggered release of SO2 from micelles can be achieved in the presence of GSH with the degradation of mPEG-P(HDI-DN) into small molecules. The in vitro experiment proved that mPEG-P(HDI-DN) micelles can enter into osteosarcoma cells and inhibit the growth of osteosarcoma cells by increasing the ROS level in cells. The in vivo experiments demonstrate that mPEG-P(HDI-DN) micelles can inhibit the growth of osteosarcoma effectively without obvious tissue toxicity. These results indicate that this chain-shattering polymeric SO2 prodrug micelle system is a promising candidate for effective SO2 based gas therapy.