Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting. (17th May 2022)

• Record Type: Journal Article
• Authors: Milburn, James; Lechiile, Kwana; Siamisang, Keatlaretse; Williams, Christopher G; Owen, Leah; Gwakuba, Ezekiel; Machiya, Tichaona; Leeme, Tshepo; Barton, Hannah E; Doyle, Ronan; Tenforde, Mark W; Mine, Madisa; Goldfarb, David M; Mokomane, Margaret; Jarvis, Joseph N
• Is Part Of: Open forum infectious diseases. Volume 9:Number 7(2022)
• Publication Date: 2022-05-17
• Subjects: cerebrospinal fluid -- encephalitis -- HIV -- human herpesvirus-6 -- meningitis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac229
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: The prevalence and clinical relevance of human herpesvirus-6 (HHV-6) detection in cerebrospinal fluid (CSF) using multiplex polymerase chain reaction (PCR) testing in patients with suspected meningoencephalitis in high human immunodeficiency virus-prevalence African settings are not known. We describe the clinical and laboratory characteristics of 13 patients with HHV-6 CSF PCR positivity in Botswana.