Altered structural cerebral cortex in children with Tourette syndrome. Issue 129 (August 2020)

• Record Type: Journal Article
• Authors: Kong, Lei; Lv, Bin; Wu, Tongning; Zhang, Jishui; Fan, Yang; Ouyang, Minhui; Huang, Hao; Peng, Yun; Liu, Yue
• Is Part Of: European journal of radiology. Issue 129(2020)
• Publication Date: 2020-08
• Subjects: Tourette syndrome -- Cortical thickness -- Cortical sulcus -- Cortical curvature; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2020.109119
• Languages: English
• ISSNs: 0720-048X

Abstract

Graphical abstract: Highlights: We use FreeSurfer software to investigate the alteration of cerebral cortex in children with Tourette syndrome. There were significant between-group differences in cortical thickness, cortical sulcus, cortical curvature, and LGI. The changes of brain structure had a certain correlation with clinical symptoms. Abstract: Purpose: In this study, we used magnetic resonance imaging (MRI) to investigate the anatomical alterations of cerebral cortex in children with Tourette syndrome (TS) and explore whether such deficits were related with their clinical symptoms. Methods: All subjects were scanned in a 3.0T MRI scanner with three-dimensional T1-weighted images (3DT1WI). Then, some surface-based features were extracted by using the FreeSurfer software. After that, the between-group differences of those features were assessed. Results: Sixty TS patients and 52 age- and gender-matched healthy control were included in this study. Surface-based analyses revealed altered cortical thickness, cortical sulcus, cortical curvature and local gyrification index (LGI) in TS group compared with healthy controls. The brain regions with significant-group differences in cortical thickness included postcentral gyrus, superiorparietal gyrus, rostral anterior cingulate cortex in the left hemisphere and frontal pole, lateral occipital gyrus, inferior temporal gyrus in the right hemisphere. In addition, the superior temporal gyrus, medial orbitofrontal gyrus, supramarginal gyrus, medial orbitofrontal gyrus, superiorparietal gyrus and lateral occipital gyrus showed significant between-group differences for cortical sulcus. Moreover, the brain regions with significant between-group differences in cortical curvature were located in caudal anterior cingulate cortex, supramarginal gyrus, inferior parietal gyrus and lateral occipital gyrus. The alteration of LGI were most prominent in the inferior temporal gyrus and insula. Additionally, there was no statistical difference in brain surface area for TS children compared with controls. Conclusion: The results of this study revealed that cortical thickness, sulcus, cortical curvature and LGI were changed in multiple brain regions for children with TS.