Is a cure for Parkinson's disease hiding inside us?. Issue 8 (August 2022)
- Record Type:
- Journal Article
- Title:
- Is a cure for Parkinson's disease hiding inside us?. Issue 8 (August 2022)
- Main Title:
- Is a cure for Parkinson's disease hiding inside us?
- Authors:
- Santos, Jaime
Pallarès, Irantzu
Ventura, Salvador - Abstract:
- Abstract : α-Synuclein (a-syn) oligomers and fibrils are behind neurodegeneration in Parkinson's disease (PD), but therapeutically targeting them is challenging. Amphipathic and cationic helical peptides inhibit amyloid formation and suppress neurotoxicity by selectively binding the solvent-accessible regions in these toxic species. Can endogenous peptides, like LL-37, constitute a new therapeutic paradigm in PD?
- Is Part Of:
- Trends in biochemical sciences. Volume 47:Issue 8(2022)
- Journal:
- Trends in biochemical sciences
- Issue:
- Volume 47:Issue 8(2022)
- Issue Display:
- Volume 47, Issue 8 (2022)
- Year:
- 2022
- Volume:
- 47
- Issue:
- 8
- Issue Sort Value:
- 2022-0047-0008-0000
- Page Start:
- 641
- Page End:
- 644
- Publication Date:
- 2022-08
- Subjects:
- Parkinson's disease -- α-synuclein -- LL-37 -- oligomer -- amyloid fibril -- disease-modifying therapy
Biochemistry -- Periodicals
572 - Journal URLs:
- http://www.sciencedirect.com/science/journal/09680004 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.tibs.2022.02.001 ↗
- Languages:
- English
- ISSNs:
- 0968-0004
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9049.546000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22558.xml