Safety assessment of the insecticidal protein IPD079Ea from the fern, Ophioglossum pendulum. (August 2022)

• Record Type: Journal Article
• Authors: Carlson, Anne B.; Mathesius, Carey A.; Ballou, Stephen; Fallers, Melissa N.; Gunderson, Tim A.; Hession, Aideen; Mirsky, Henry; Stolte, Brian; Zhang, John; Woods, Rachel M.; Herman, Rod A.; Roper, Jason M.
• Is Part Of: Food and chemical toxicology. Volume 166(2022)
• Publication Date: 2022-08
• Subjects: Biotechnology -- Ophioglossum pendulum -- IPD079Ea -- PIP -- Insecticide -- Western corn rootworm; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2022.113187
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: As agricultural biotechnology continues to develop solutions for addressing crop pests through newly expressed proteins from novel source organisms, with different modes or sites of action and/or different spectra of activity, the safety of these proteins will be assessed. The results of hazard-identification and characterization studies for the insecticidal protein IPD079Ea, which is derived from a fern ( Ophioglossum pendulum ) and active against the maize pest western corn rootworm ( Diabrotica virgifera virgifera, Coleoptera: Chrysomelidae) are provided. Collectively these results indicate that IPD079Ea is unlikely to present a hazard to human or animal health and support the safety of genetically modified maize expressing IPD079Ea. Highlights: IPD079Ea is a novel insecticidal protein derived from Ophioglossum pendulum. IPD079Ea offers a new site of action to protect against WCR in GM maize. IPD079Ea protein safety was assessed through a weight-of-evidence approach. No IPD079Ea protein toxin or allergen hazard was identified. IPD079Ea is unlikely to be a hazard to human or animal health.