Antioxidants reduce the heterogeneity of the intracellular glutathione level in senescent cell population of human dermal fibroblasts. Issue 3 (June 2020)

• Record Type: Journal Article
• Authors: Lee, Ki Baek; Shin, Ji-Woong; Kwon, Mee-ae; Kang, Hyewon; Kim, Hye-Mi; Lee, Seok-Jin; Jeong, Eui Man; Kang, Heun-Soo; Kim, In-Gyu
• Is Part Of: Journal of dermatological science. Volume 98:Issue 3(2020)
• Page Start: 195
• Page End: 198
• Publication Date: 2020-06
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2020.04.003
• Languages: English
• ISSNs: 0923-1811

Abstract

Highlights: Senescent HDFs showed reduced GSH levels, increased its heterogeneity, but exhibited a similar GSH regeneration activity compared with young HDFs. GSH level in senescent HDF was inversely correlated with senescence-associated phenotypes. Treatment with antioxidants showed a reduction of GSH level heterogeneity but no effect on mean GSH level. This antioxidant effect on GSH levels explain why antioxidants exhibit a limited effect on preventing HDF senescence.