Cytotoxic effect of functionalized superparamagnetic samarium doped iron oxide nanoparticles for hyperthermia application. Issue 17 (1st September 2022)

• Record Type: Journal Article
• Authors: Hemalatha, K.; Alamelumangai, K.; Arulmozhi, R.; Chandunika, R.K.; Sahu, Niroj Kumar; Parthipan, G.; Rajaram, Muralidharan
• Is Part Of: Ceramics international. Volume 48:Issue 17(2022)
• Page Start: 24485
• Page End: 24495
• Publication Date: 2022-09-01
• Subjects: Magnetic fluid hyperthermia -- Superparamagnetic -- Oleylamine -- Polyvinyl alcohol -- Samarium doped magnetite -- Specific absorption rate -- Cytotoxicity; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2022.05.078
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Magnetic Fluid Hyperthermia (MFH) is an emerging and safe technique for cancer treatment. Radiotherapy and Chemotherapy are widely adopted techniques for treating cancer but cause damage to the nearby healthy tissue. This paves the way for hyperthermia treatment for cancer. Since healthy cells are more heat-tolerant than malignant cells, magnetic nanoparticles with superparamagnetic properties were used in hyperthermia treatment. Surface modified magnetite (Fe3 O4 ) iron oxide nanoparticles with enhanced stability, solubility, bio-compatibility and magnetic property were employed in hyperthermia treatment. In the present study, Superparamagnetic Samarium doped magnetite (Fe3 O4 :Sm) nanoparticles were functionalized with Oleylamine (OAm) and polyvinyl alcohol (PVA) by the sol-gel process. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and UV–Visible diffuse reflectance spectroscopy (UV-DRS), Thermogravimetric analysis (TGA) and Vibrating Sample Magnetometer (VSM). From XRD data, the crystallite size of oleylamine coated samarium doped magnetite (OAm–Fe3 O4 :Sm) and PVA-coated samarium doped Fe3 O4 (PVA- Fe3 O4 :Sm) were found to be 9.5 nm and 10.9 nm, respectively. TEM images of the functionalized nanoparticles were visualized as a spherical structure with reduced agglomeration. UV-DRS gives the bandgap value of OAm–Fe3 O4 :Sm and PVA- Fe3 O4 :Sm coated samarium doped magnetite to be 2.3 eV and 2 eV respectively. VSM measurement of OAm-Fe3 O4 :Sm and PVA- Fe3 O4 :Sm coated, showed superparamagnetic behaviour. The cytotoxicity study on the L929 cell line shows that both oleylamine and PVA-coated samarium doped magnetite were less toxic and biocompatible compared to the uncoated Fe3 O4 :Sm. The hyperthermia study reveals a rise in temperature within a few seconds with a high Specific Absorption Rate (SAR) value, confirming that the functionalized Samarium doped Fe3 O4 was an effective nanomaterial for hyperthermia application.