Design of Copper Microfabricated Potentiometric Sensor for in‐line Monitoring of Neostigmine Degradation Kinetics. Issue 5 (16th February 2021)

• Record Type: Journal Article
• Authors: El‐Sayed, Ghada M.; El Mously, Dina A.; Mostafa, Nadia M.; Hassan, Nagiba Y.; Mahmoud, Amr M.
• Is Part Of: Electroanalysis. Volume 33:Issue 5(2021)
• Page Start: 1215
• Page End: 1224
• Publication Date: 2021-02-16
• Subjects: Copper electrode -- Degradation kinetics -- In-line monitoring -- Microfabrication -- Neostigmine; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202060536
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: The quality of pharmaceutical products is critical for human health. Drug development requires tools to assess the presence of degradation products and contaminants during the manufacturing and storage processes. Accelerated stress degradation and kinetic studies play a vital role in predicting final product stability. This work describes the design of potentiometric sensor based on copper microfabricated electrodes for in‐line tracking the degradation kinetics of neostigmine. The proposed electrochemical technique provides a continuous profile for the hydrolysis of NEO under different temperatures and pH. The hydrolysis activation energy was found to be 18.88 kcal mol −1 which was aligned with the reported hydrolysable ester values. Consequently, the kinetic data analysis is crucial to predict the optimum analysis and storage conditions. Abstract :