Voltammetric Detection of Captopril in a Commercial Drug Using a Gold‐Copper Metal‐organic Framework Nanocomposite Modified Electrode. Issue 5 (28th January 2021)

• Record Type: Journal Article
• Authors: da Silva, Diana Maria; Carneiro da Cunha Areias, Madalena
• Is Part Of: Electroanalysis. Volume 33:Issue 5(2021)
• Page Start: 1255
• Page End: 1263
• Publication Date: 2021-01-28
• Subjects: Captopril -- modified glassy carbon electrode -- gold-copper-1, 3, 5-benzenetricarboxylate nanocomposite -- cyclic voltammetry; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202060271
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: We report the application of an electrochemical sensor based on gold‐copper metal‐organic framework immobilized on the surface of a glassy carbon electrode to the detection of captopril (CAP), an angiotensin‐converting enzyme inhibitor. Cyclic voltammetric studies showed that the joint action of gold nanoparticles and copper‐1, 3, 5‐benzenetricarboxylate (Cu−BTC) enhanced the electrochemical response to the Cu‐captopril complex that is adsorbed onto the surface of the electrode. Release of gold nanoparticles from Au@Cu−BTC not only increased the conductivity of the electrode but also provided a more favorable environment for the deposition of reduced Cu that is catalytically renewed on the electrode surface. The anodic current of the Cu (II) −CAP oxidation peak varied linearly within two concentration ranges, namely 0.5 to 7.0 μmol L −1 and 10 to 2500 μmol L −1, with a limit of detection of 0.047 μmol L −1 . The mean recovery for the determination of captopril in commercial tablets was 100.3 % suggesting that the method has considerable potential for future industrial applications. Abstract :