Anti-synthetase syndrome in a patient with recurrent episodes of pulmonary embolism: a case report. Issue 3 (3rd May 2020)

• Record Type: Journal Article
• Authors: Eltelbany, Moemen; Huang, Yuting; Sandhu, Preetinder; Akbaryeh, Abdul; Iloh, Nzube; Tran, Dena H.; Mikdashi, Jamal; Bakhtawar, Iram
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 10:Issue 3(2020)
• Page Start: 255
• Page End: 257
• Publication Date: 2020-05-03
• Subjects: Anti-synthetase syndrome -- EJ-antibody -- recurrent PE/DVT -- interstitial Lung Disease -- hemoptysis; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2020.1769421
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Anti-synthetase syndrome (ASS) is characterized by myositis that is associated with progressive interstitial lung disease (ILD). The prognosis of the disease is affected by the type and degree of pulmonary involvement. We report a rare case of ASS with positive Anti-EJ antibody presenting with a combination of recurrent deep vein thrombosis/pulmonary embolism (DVT/PE) and progressive ILD. This case demonstrates the delayed diagnosis of ASS and the association of thromboembolic disease and ASS. Physicians should have a high index of suspicion for ASS, as early diagnosis and management alters the morbidity and prognosis of patients with ASS. Abbreviations: ASS: Anti-synthetase syndrome; Ab: Antibody; Ag: Antigen; ANA: Anti-nuclear antibodies; CK: Creatine kinase; CRP: C-reactive protein; DVT: Deep Vein Thrombosis; ESR: Erythrocyte Sedimentation Rate; ILD: Interstitial lung disease; PE: Pulmonary Embolism; CTA: CT Angiography