Aldosterone to Active Renin Ratio Is Associated With Nocturnal Blood Pressure in Obese and Treated Hypertensive Patients: The Styrian Hypertension Study. Issue 4 (26th March 2014)

• Record Type: Journal Article
• Authors: Grübler, Martin R.; Kienreich, Katharina; Gaksch, Martin; Verheyen, Nicolas; Fahrleitner‐Pammer, Astrid; Schmid, Johannes; Grogorenz, Jana; Ablasser, Klemens; Pieske, Burkert; Tomaschitz, Andreas; Pilz, Stefan
• Is Part Of: Journal of clinical hypertension. Volume 16:Issue 4(2014:Apr.)
• Page Start: 289
• Page End: 294
• Publication Date: 2014-03-26
• Subjects: Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.12274
• Languages: English
• ISSNs: 1524-6175

Abstract

Abstract : High aldosterone levels are considered to play a key role in arterial hypertension. Data on the relationship between the aldosterone to active renin ratio (AARR), a quantity of aldosterone excess, and ambulatory blood pressure (BP) monitoring (ABPM) during the night are, however, sparse. Hypertensive patients were recruited from local outpatient clinics who underwent 24‐hour urine collection and in parallel ABPM. Plasma aldosterone and renin concentrations were measured by radioimmunoassay. A total of 211 patients (age, 60.2±10.2 years; 51.9% female) with a mean systolic/diastolic ABPM value of 128.7±12.8/77.1±9.2 mm Hg were evaluated. In backwards linear regression analyses adjusted for age, sex, body mass index, smoking, glomerular filtration rate, hemoglobin A1c, N‐terminal prohormone of brain natriuretic peptide, urinary sodium/potassium ratio, and ongoing antihypertensive medication, AARR was significantly associated with nocturnal systolic (ß‐coefficient: 0.177; P =.017) and diastolic BP (ß‐coefficient: 0.162; P =.027). In patients with arterial hypertension, a significant association between AARR and nighttime BP even after adjustment for a broad panel of confounders was found.