QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report. Issue 2 (3rd March 2020)

• Record Type: Journal Article
• Authors: Ali, Zain; Khan, Mariya; Ullah, Waqas; Kpehor, Atsoufui A.; Cheema, Muhammad Arslan
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 10:Issue 2(2020)
• Page Start: 151
• Page End: 153
• Publication Date: 2020-03-03
• Subjects: Diphenhydramine toxicity -- anticholinergic toxidrome -- rhabdomyolysis -- QTC prolongation; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2020.1749511
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes.