Synthesis and herbicidal activity of new pyrazole ketone derivatives. (6th October 2020)

• Record Type: Journal Article
• Authors: Fu, Qing; Kang, Sheng-Jie; Zhong, Liang-Kun; Chen, Jie; Tan, Cheng-Xia; Weng, Jian-Quan; Xu, Tian-Ming; Liu, Xing-Hai
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 196:Number 2(2021)
• Page Start: 200
• Page End: 205
• Publication Date: 2020-10-06
• Subjects: Synthesis -- pyrazole derivatives -- molecular docking -- herbicidal activity; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2020.1828884
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: A series of pyrazole derivatives was designed according to prodrug strategy. These compounds were synthesized via eight steps and their structures were confirmed by 1 H NMR spectroscopy and MS. The preliminary herbicidal bioassay results indicated that the title pyrazole ketone compounds exhibited low herbicidal activity against six weeds at 150 g/ha, which is weaker than that of the commercial HPPD herbicide topramezone. The docking results showed that the binding mode of the key intermediate (3-(2-(2-fluorophenoxy)ethoxy)-2-methyl-4-(methylsulfonyl)phenyl)(5-hydroxy-1, 3-dimethyl-1H-pyrazol-4-yl)methanone is the same as the reported inhibitor DAS689 in the complex. Graphical Abstract: