Intrinsic Cortico-Subcortical Functional Connectivity in Developmental Dyslexia and Developmental Coordination Disorder. Issue 1 (6th April 2020)

• Record Type: Journal Article
• Authors: Cignetti, Fabien; Nemmi, Federico; Vaugoyeau, Marianne; Girard, Nadine; Albaret, Jean-Michel; Chaix, Yves; Péran, Patrice; Assaiante, Christine
• Is Part Of: Cerebral cortex communications. Volume 1:Issue 1(2020)
• Publication Date: 2020-04-06
• Subjects: cortico-subcortical networks -- developmental coordination disorder -- developmental dyslexia -- machine learning -- resting-state fMRI; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/texcom/tgaa011
• Languages: English
• ISSNs: 2632-7376

Abstract

Abstract: Developmental dyslexia (DD) and developmental coordination disorder (DCD) are distinct diagnostic disorders. However, they also frequently co-occur and may share a common etiology. It was proposed conceptually a neural network framework that explains differences and commonalities between DD and DCD through impairments of distinct or intertwined cortico-subcortical connectivity pathways. The present study addressed this issue by exploring intrinsic cortico-striatal and cortico-cerebellar functional connectivity in a large ( n = 136) resting-state fMRI cohort study of 8–12-year-old children with typical development and with DD and/or DCD. We delineated a set of cortico-subcortical functional circuits believed to be associated with the brain's main functions (visual, somatomotor, dorsal attention, ventral attention, limbic, frontoparietal control, and default-mode). Next, we assessed, using general linear and multiple kernel models, whether and which circuits distinguished between the groups. Findings revealed that somatomotor cortico-cerebellar and frontoparietal cortico-striatal circuits are affected in the presence of DCD, including abnormalities in cortico-cerebellar connections targeting motor-related regions and cortico-striatal connections mapping onto posterior parietal cortex. Thus, DCD but not DD may be considered as an impairment of cortico-subcortical functional circuits.