Neuropsychiatric symptoms in a occipito-temporal infarction with remarkable long-term functional recovery. (April 2021)

• Record Type: Journal Article
• Authors: Tanev, Kaloyan S.; Federico, Lydia E.; Sydnor, Valerie J.; Leveroni, Catherine L.; Hassan, Khalid; Biffi, Alessandro
• Is Part Of: Cortex. Volume 137(2021)
• Page Start: 205
• Page End: 214
• Publication Date: 2021-04
• Subjects: Occipital-temporal stroke -- Posterior cortical infarct -- Topographical disorientation -- Quadrantanopsia -- Cognitive rehabilitation; Neuropsychology -- Periodicals; Nervous system -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Behavior -- Periodicals; Neurology -- Periodicals; 612.825
• DOI: 10.1016/j.cortex.2021.01.013
• Languages: English
• ISSNs: 0010-9452

Abstract

Abstract: Posterior circulation infarctions (PCI) constitute 5–25% of ischemic strokes. PCI of the occipital lobe present with a panoply of symptoms including quadrantanopsia, topographical disorientation, and executive dysfunction. Long-term cognitive recovery after PCI is not well described. However, the adult brain is remarkably plastic, capable of adapting and remodeling. We describe a 43-year-old right-handed woman who complained of black spots in both eyes, headaches, photophobia, and a feeling she would faint. Initial neurological exam and a CT scan were normal; she was diagnosed with ocular migraine. A second neurological exam a week later showed left superior quadrantopsia; an MRI scan suggested right occipito-temporal infarct. In subsequent months, the patient complained of fatigue, quadrantanopsia, memory problems, and topographical disorientation. The patient participated in multi-modality treatment, and in self-directed arts projects and physical activities. Six years later, she reported noticeable improvements in cognition and daily functioning, which were documented on neurocognitive testing. Comparison between initial and subsequent MRIs using FreeSurfer 5.3 identified neuroplastic brain changes in areas serving similar functions to the areas injured from the stroke. The case illustrates the neuropsychiatric presentation after right occipito-temporal stroke, the value of formal and self-directed cognitive rehabilitation, the extended time to cognitive recovery, and the ability of the brain to undergo neuroplastic changes.