Neuro-Ophthalmic Manifestations of HIV Infection. (2nd October 2020)

• Record Type: Journal Article
• Authors: Gordon, Lynn K.; Danesh-Meyer, Helen
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 7(2020)
• Page Start: 1085
• Page End: 1093
• Publication Date: 2020-10-02
• Subjects: HIV -- optic neuropathy -- papilledema -- headache -- syphilis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1704024
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To review the broad spectrum of clinical neuro-ophthalmic presentations associated with human immunodeficiency virus (HIV) infection. Methods : Critical review of the literature regarding neuro-ophthalmic consequences of HIV infection and its sequelae. Results : Neuro-ophthalmological diseases are common in both asymptomatic HIV-positive patients and those who profound immunosuppression with acquired immune deficiency syndrome (AIDS). Neuro-ophthalmic manifestations of HIV infection can involve the afferent or efferent visual pathway. Common clinical presentations include headache, papilledema, chorioretinitis, optic nerve involvement, meningitis, and cranial nerve palsies. Other neuro-ophthalmic manifestations include involvement of the visual pathway in the brain producing visual field defects such as occur in progressive multifocal encephalopathy. Pupil abnormalities have also been reported. Discussion : Neuro-ophthalmic consequences of HIV are important to recognize as it is critical to identify underlying neoplastic or infectious diseases which could be amenable to treatment.